PCK1 is a key regulator of metabolic and mitochondrial functions in renal tubular cells
Thomas Verissimo, Delal Dalga, Grégoire Arnoux, Imene B. Sakhi, Anna Faivre, Hannah Auwerx, Soline Bourgeois, Deborah Paolucci, Quentin Gex, Joseph M. Rutkowski, David Legouis, Carsten A. Wagner, Andrew M. Hall, Sophie de Seigneux
Abstract
Phosphoenolpyruvate carboxykinase 1 (PCK1) is highly expressed in the proximal tubule. We show here that this enzyme is crucial for the maintenance of normal tubular physiology, lactate, and glucose homeostasis. PCK1 is a regulator of acid-base balance and ammoniagenesis. Preventing PCK1 downregulation during renal injury improves renal function, rendering it an important target during renal disease.
Topics & Concepts
RegulatorPhosphoenolpyruvate carboxykinaseDownregulation and upregulationRenal functionKidney tubulesHomeostasisChemistryGluconeogenesisProximal tubuleKidneyEndocrinologyInternal medicineBiologyCell biologyEnzymeBiochemistryMedicineGeneRenal function and acid-base balanceIon Transport and Channel RegulationBiomedical Research and Pathophysiology