Grass Carp Reovirus Induces Formation of Lipid Droplets as Sites for Its Replication and Assembly
Libo He, Qian Wang, Xinyu Liang, Hanyue Wang, Pengfei Chu, Cheng Yang, Yongming Li, Lanjie Liao, Zuoyan Zhu, Yaping Wang
Abstract
fatty acid synthesis induced accumulation of LDs, which act as sites or scaffolds for GCRV replication and assembly. Our findings illustrate a typical example of how the virus hijacks cellular organelles for replication and assembly and hence may provide new insights for the prevention and control of GCRV.
Topics & Concepts
Grass carpViral replicationLipid dropletBiologyLipid metabolismViral life cycleVirologyIntracellular parasiteIntracellularCell biologyVirusBiochemistryFish <Actinopterygii>FisheryLipid metabolism and biosynthesisPhysiological and biochemical adaptationsViral Infectious Diseases and Gene Expression in Insects