Organocatalytic stereoselective 1,6-addition of thiolacetic acids to alkynyl indole imine methides: access to axially chiral sulfur-containing tetrasubstituted allenes
Ziyang Wang, Xiao Lin, Xuling Chen, Pengfei Li, Wenjun Li
Abstract
A chiral phosphoric acid-catalyzed enantioselective 1,6-conjugate addition of thiolacetic acid to alkynyl indole imine methide <italic>in situ</italic> formed from α-(3-indolyl) propargylic alcohol has been established.
Topics & Concepts
ChemistryImineStereoselectivityIndole testPhosphoric acidEnantioselective synthesisOrganic chemistryConjugateSulfurOrganocatalysisCatalysisMedicinal chemistryMathematicsMathematical analysisAxial and Atropisomeric Chirality SynthesisSynthesis of Indole DerivativesAsymmetric Synthesis and Catalysis