Molecular pathology of Usher 1B patient-derived retinal organoids at single cell resolution
Yeh Chwan Leong, Valentina Di Foggia, Hema Pramod, Maria Bitner‐Glindzicz, Aara Patel, Jane C. Sowden
Abstract
Müller cells, pointing to the defensive mechanisms that mitigate photoreceptor cell death. This first human model for USH1B-RP provides a representation of patient retina in vivo relevant for development of therapeutic strategies.
Topics & Concepts
BiologyOrganoidRetinalComputational biologyPathologyCell biologyBotanyMedicineRetinal Development and DisordersOcular Oncology and TreatmentsImmunotherapy and Immune Responses