Is Disrupted Nucleotide-Substrate Cooperativity a Common Trait for Cushing's Syndrome Driving Mutations of Protein Kinase A?
Caitlin Walker, Yingjie Wang, Cristina Olivieri, Manu Veliparambil Subrahmanian, Jiali Gao, David Bernlohr, Davide Calebiro, Susan S. Taylor, Gianluigi Veglia
Topics & Concepts
Allosteric regulationCooperativityAllosteric enzymeMutationProtein subunitMutantProtein kinase ABiologyKinaseChemistryBiophysicsGeneticsBiochemistryEnzymeGeneHormonal Regulation and HypertensionPituitary Gland Disorders and TreatmentsCancer, Hypoxia, and Metabolism