Modeling Infection and Tropism of Human Parainfluenza Virus Type 3 in Ferrets
Laurine C. Rijsbergen, Katharina S. Schmitz, Lineke Begeman, Jennifer Drew-Bear, Lennert Gommers, Mart M. Lamers, Alexander L. Greninger, Bart L. Haagmans, Matteo Porotto, Rik L. de Swart, Anne Moscona, Rory D. de Vries
Abstract
models, providing a platform to study approaches to prevent and treat HPIV-3 infection. Although we did not detect ferret-to-ferret transmission in our studies, these studies lay the groundwork for further refinement of the ferret model to immunocompromised ferrets, allowing for studies of severe HPIV-3-associated disease. Such models for preclinical evaluation of prophylaxis and antivirals can contribute to reducing the global health burden of HPIV-3.
Topics & Concepts
TropismHuman Parainfluenza VirusVirologyBiologyIn vivoAntibodyImmunologyTissue tropismViral replicationEx vivoVirusRespiratory tractRespiratory systemAnatomyBiotechnologyRespiratory viral infections researchTracheal and airway disordersCongenital Diaphragmatic Hernia Studies