The role of N6-methyladenosine (m6A) in kidney diseases
Luling You, Zhongyu Han, Zhongyu Han, Hao Chen, Liuyan Chen, Yumeng Lin, Binjian Wang, Yiyue Fan, Meiqi Zhang, Ji Luo, Fang Peng, Yue Ma, Yanmei Wang, Yuan Lan, Zhongyu Han, Zhongyu Han
Abstract
Chemical modifications are a specific and efficient way to regulate the function of biological macromolecules. Among them, RNA molecules exhibit a variety of modifications that play important regulatory roles in various biological processes. More than 170 modifications have been identified in RNA molecules, among which the most common internal modifications include N6-methyladenine (m 6 A), n1-methyladenosine (m 1 A), 5-methylcytosine (m 5 C), and 7-methylguanine nucleotide (m 7 G). The most widely affected RNA modification is m 6 A, whose writers, readers, and erasers all have regulatory effects on RNA localization, splicing, translation, and degradation. These functions, in turn, affect RNA functionality and disease development. RNA modifications, especially m 6 A, play a unique role in renal cell carcinoma disease. In this manuscript, we will focus on the biological roles of m6A in renal diseases such as acute kidney injury, chronic kidney disease, lupus nephritis, diabetic kidney disease, and renal cancer.