Guanylate binding protein 5 accelerates gastric cancer progression via the <i>JAK1-STAT1/GBP5/CXCL8</i> positive feedback loop.
Fengyu Cao, Chenhong Wang, Xiang Li, Mingzhen Ma, Gong-Cai Tao, Chao Yang, Kai Li, Xiaobo He, Shilun Tong, Qingchuan Zhao, Song Su, Dan Song, Yongbin Zheng
Abstract
as a predictive biomarker and novel target for GC intervention.
Topics & Concepts
STAT proteinCancer researchSTAT1Janus kinaseSTAT3BiologyTumor microenvironmentSignal transductionDownregulation and upregulationChemistryCell biologyGeneBiochemistryTumor cellsFerroptosis and cancer prognosisRNA modifications and cancerCytokine Signaling Pathways and Interactions