DNA-Sensing Antiviral Innate Immunity in Poxvirus Infection
Yue Lu, Leiliang Zhang
Abstract
As pattern recognition receptors, cytosolic DNA sensors quickly induce an effective innate immune response. Poxvirus, a large DNA virus, is capable of evading the host antiviral innate immune response. In this review, we summarize the latest studies on how poxvirus is sensed by the host innate immune system and how poxvirus-encoded proteins antagonize DNA sensors. A comprehensive understanding of the interplay between poxvirus and DNA-sensing antiviral immune responses of the host will contribute to the development of new antiviral therapies and vaccines in the future.
Topics & Concepts
Innate immune systemBiologyImmune systemPattern recognition receptorVirologyImmunityDNAVirusImmunologyHost (biology)DNA virusPoxviridaeDNA vaccinationVacciniaGenomeGeneGeneticsRecombinant DNAImmunizationinterferon and immune responsesHerpesvirus Infections and TreatmentsViral Infections and Vectors