Correlation of Immunogenicity and Reactogenicity of BNT162b2 and CoronaVac SARS-CoV-2 Vaccines
Ruiqi Zhang, Ka‐Yi Leung, Danlei Liu, Yujing Fan, Lu Lu, Pui-Chun Chan, Kelvin Kai‐Wang To, Honglin Chen, Kwok‐Yung Yuen, Kwok‐Hung Chan, Ivan Fan‐Ngai Hung
Abstract
Effective vaccines against SARS-CoV-2 are vital tools for containing the COVID-19 pandemic by increasing population immunity. While currently available vaccines can elicit antibody response against SARS-CoV-2 with high efficacy, the associated side effects may cause vaccine hesitancy. Our work is important in that we have thoroughly analyzed the correlation between immunogenicity and reactogenicity of two COVID-19 vaccines (BNT162b2 and CoronaVac) in the study. Our results showed that women had higher levels of neutralizing antibodies than men after receiving BNT162b2 or CoronaVac. Furthermore, a low correlation was observed between day 21 vMN titer and local reactions (redness and itching) in females, as well as between day 56 vMN titer and fever in males receiving BNT162b2. Thus, common side effects are not always a negative impact of vaccination but may serve as an indicator of immunogenicity of vaccines. Our study may help in increasing the public's acceptance and confidence over COVID-19 vaccination and ultimately achieving the goal of containing COVID-19 pandemic.