Non-coding RNA in cancer
Huiwen Yan, Pengcheng Bu
Abstract
Majority of the human genome is transcribed to RNAs that do not encode proteins. These non-coding RNAs (ncRNAs) play crucial roles in regulating the initiation and progression of various cancers. Given the importance of the ncRNAs, the roles of ncRNAs in cancers have been reviewed elsewhere. Thus, in this review, we mainly focus on the recent studies of the function, regulatory mechanism and therapeutic potential of the ncRNAs including microRNA (miRNA), long ncRNA (lncRNA), circular RNA (circRNA) and PIWI interacting RNA (piRNA), in different type of cancers.
Topics & Concepts
Non-coding RNAmicroRNARNABiologyPiwi-interacting RNAComputational biologyENCODELong non-coding RNACircular RNAGenomeSmall nucleolar RNAGeneticsMechanism (biology)Function (biology)GeneRNA interferenceEpistemologyPhilosophyCircular RNAs in diseasesCancer-related molecular mechanisms researchMicroRNA in disease regulation