Synthesis and SAR studies of novel 1,2,4-oxadiazole-sulfonamide based compounds as potential anticancer agents for colorectal cancer therapy
Farheen Shamsi, Phool Hasan, Aarfa Queen, Afzal Hussain, Parvez Κhan, Bushra Zeya, Hannah M. King, Sandeep Rana, Jered C. Garrison, Mohamed F. Alajmi, M. Moshahid A. Rizvi, Muhammad Zahid, Md. Imtaiyaz Hassan, Mohammad Abid
Topics & Concepts
ChemistryIC50SulfonamideColorectal cancerCarbonic anhydraseDoxorubicinPharmacologyPotencyThiazoleOxadiazoleDrugCancerStereochemistryCancer researchCombinatorial chemistryBiochemistryEnzymeIn vitroChemotherapyMedicineInternal medicineOrganic chemistryEnzyme function and inhibitionSynthesis and Biological EvaluationPhenothiazines and Benzothiazines Synthesis and Activities