Design, synthesis and<i>in silico</i>studies of new quinazolinone derivatives as antitumor PARP-1 inhibitors
Sayed K. Ramadan, Eman Z. Elrazaz, Khaled A. M. Abouzid, Abeer M. El‐Naggar
Abstract
ADMET study was performed. The results of this study revealed that some of the newly synthesized compounds could serve as a new framework to discover new PARP-1 inhibitors with anti-cancer activity.
Topics & Concepts
QuinazolinoneOlaparibChemistryPoly ADP ribose polymeraseIn silicoCombinatorial chemistryQuantitative structure–activity relationshipDocking (animal)StereochemistryCell cycle checkpointCell cycleApoptosisBiochemistryEnzymePolymeraseNursingMedicineGenePARP inhibition in cancer therapyIntegrated Circuits and Semiconductor Failure AnalysisToxin Mechanisms and Immunotoxins