Melatonin improves mitochondrial biogenesis through the AMPK/PGC1α pathway to attenuate ischemia/reperfusion-induced myocardial damage
Xueyan Qi, Jin Wang
Abstract
attenuated the protective effects of melatonin on cardiomyocyte viability, thereby impairing mitochondrial bioenergetics, disrupting the mitochondrial morphology, and activating mitochondrial apoptosis. Thus, H/R injury suppressed mitochondrial biogenesis, while melatonin activated the AMPK/PGC1α pathway and restored mitochondrial biogenesis, ultimately protecting the reperfused heart.
Topics & Concepts
AMPKMelatoninMitochondrial biogenesisReperfusion injuryIschemiaMitochondrionCardiologyInternal medicineMedicineChemistryEnzymeProtein kinase ABiochemistryDiet, Metabolism, and DiseaseMitochondrial Function and PathologyDiet and metabolism studies