Berberine and Emodin abrogates breast cancer growth and facilitates apoptosis through inactivation of SIK3-induced mTOR and Akt signaling pathway

Lavanya Ponnusamy, Gugan Kothandan, Ravi Manoharan

2020Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease75 citationsDOI

Topics & Concepts

Protein kinase BPI3K/AKT/mTOR pathwayCancer researchCarcinogenesisBreast cancerCell cycleCell growthCancerApoptosisChemistryBiologySignal transductionCell biologyMedicineInternal medicineBiochemistryBerberine and alkaloids researchSynthesis and Biological ActivityPI3K/AKT/mTOR signaling in cancer