Predictors of the change in burden, strain, mood, and quality of life among caregivers of Parkinson's disease patients
Diego Santos‐García, Teresa de Deus Fonticoba, Carlos Cores Bartolomé, María Cristina Íñiguez Alvarado, Maria J. Feal Panceiras, E. Suárez Castro, Héctor Canfield, Cristina Martínez Miró, Silvia Jesús, Miquel Aguilar, Pau Pástor, Lluís Planellás, Marina Cosgaya, Juan García Caldentey, Núria Caballol, Inés Legarda, Jorge Hernández‐Vara, Iria Cabo, Lydia López Manzanares, Isabel González Aramburu, María A. Ávila Rivera, Víctor Gómez Mayordomo, Víctor Nogueira, Víctor Puente, Julio Dotor García‐Soto, Carmen Borrué, Berta Solano Vila, María Álvarez Saúco, Lydia Vela, Sonia Escalante, Esther Cubo, Francisco Carrillo Padilla, Juan Carlos Martínez‐Castrillo, Pilar Sánchez Alonso, Maria G. Alonso Losada, Núria López Ariztegui, Itziar Gastón, Jaime Kulisevsky, Marta Blázquez Estrada, Manuel Seijo, Javier Ruiz‐Martínez, Caridad Valero, Mónica Kurtis, Oriol de Fàbregues, Jessica González Ardura, Rubén Alonso Redondo, Carlos Ordás, Luis M. López DíazL, Darrian McAfee, Pablo Martínez‐Martín, Pablo Mir, COPPADIS Study Group
Abstract
BACKGROUND AND OBJECTIVE: Caregiver burden in Parkinson's disease (PD) has been studied in many cross-sectional studies but poorly in longitudinal ones. The aim of the present study was to analyze the change in burden, strain, mood, and quality of life (QoL) after a 2-year follow-up in a cohort of caregivers of patients with PD and also to identify predictors of these changes. PATIENTS AND METHODS: PD patients and their caregivers who were recruited from January/2016 to November/2017 from 35 centers of Spain from the COPPADIS cohort were included in the study. They were evaluated again at 2-year follow-up. Caregivers completed the Zarit Caregiver Burden Inventory (ZCBI), Caregiver Strain Index (CSI), Beck Depression Inventory-II (BDI-II), and EUROHIS-QOL 8-item index (EUROHIS-QOL8) at baseline (V0) and at 2-year follow-up (V2). General linear model repeated measure and lineal regression models were applied. RESULTS: Significant changes, indicating an impairment, were detected on the total score of the ZCBI (p < 0.0001), CSI (p < 0.0001), BDI-II (p = 0.024), and EUROHIS-QOL8 (p = 0.002) in 192 PD caregivers (58.82 ± 11.71 years old; 69.3% were females). Mood impairment (BDI-II; β = 0.652; p < 0.0001) in patients from V0 to V2 was the strongest factor associated with caregiver's mood impairment after the 2-year follow-up. Caregiver's mood impairment was the strongest factor associated with an increase from V0 to V2 on the total score of the ZCBI (β = 0.416; p < 0.0001), CSI (β = 0.277; p = 0.001), and EUROHIS-QOL (β = 0.397; p = 0.002). CONCLUSION: Burden, strain, mood, and QoL were impaired in caregivers of PD patients after a 2-year follow-up. Mood changes in both the patient and the caregiver are key aspects related to caregiver burden increase.