Synthetic methods for compounds containing fluoro-lactam units
Xin Wang, Lei Jia, Guofeng Li, Jianping Meng, Chen Li, Jiazhu Li, Kai Sun
Abstract
In recent years, considerable attention has been devoted to the exploration of novel synthetic methods for fluoro-lactams due to their significant biological and pharmaceutical activities. This review summarizes recently established strategies for synthesizing fluorine-substituted lactams, including fluoro-β-lactams, fluoro-γ-lactams, and fluoro-δ-lactams. Additionally, the reaction scopes, limitations, and mechanisms are discussed.
Topics & Concepts
LactamBeta-lactamCombinatorial chemistryChemistryStereochemistryAntibioticsBiochemistryFluorine in Organic ChemistrySynthesis of β-Lactam CompoundsSynthesis and Biological Evaluation