Histidine-based coordinative polymers for efficient intracellular protein delivery <i>via</i> enhanced protein binding, cellular uptake, and endosomal escape
Chang-Yuan Chen, Peng Gao, Hui Wang, Yiyun Cheng, Jia Lv
Abstract
-coordinated polymer formed large-sized aggregates with cargo proteins and showed insufficient protein release after endocytosis. The results obtained in this study provided new insight into the development of coordinative polymer-based protein delivery systems.
Topics & Concepts
EndosomeIntracellularHistidineChemistryBiophysicsCell biologyPlasma protein bindingIntracellular transportBiochemistryBiologyAmino acidRNA Interference and Gene DeliveryAdvanced biosensing and bioanalysis techniquesSupramolecular Self-Assembly in Materials