Experimental validation of a mean systemic pressure analog against zero-flow measurements in porcine VA-ECMO
Per Werner Möller, Paul Philipp Heinisch, Anisa Hana, Kaspar F. Bachmann, Sören Söndergaard, Stephan M. Jakob, Jukka Takala, David Berger
Abstract
This is the first study ever to validate the mean systemic pressure analog (Pmsa) against the reference mean systemic filling pressure (MSFP) determined at full arterio-venous pressure equilibrium. Using a porcine ECMO model with clinically relevant levels of vasoconstriction and volume expansion, we showed that Pmsa accurately estimated absolute and changing values of MSFP, with a poor between-method precision. The within-method precision of Pmsa was excellent.
Topics & Concepts
MedicineZero (linguistics)AnesthesiaCardiologyInternal medicinePhilosophyLinguisticsHemodynamic Monitoring and TherapyCardiovascular Function and Risk FactorsAdvanced Sensor Technologies Research