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Pathological angiogenesis in retinopathy engages cellular senescence and is amenable to therapeutic elimination via BCL-xL inhibition

Sergio Crespo‐Garcia, Pamela R. Tsuruda, Agnieszka Dejda, Rathi D. Ryan, Frédérik Fournier, S. Chaney, Frédérique Pilon, Taner Dogan, Gaël Cagnone, Priyanka Patel, Manuel Buscarlet, Sonali Dasgupta, Gabrielle Girouard, Surabhi Rao, Ariel M. Wilson, Robert O’Brien, Rachel Juneau, Vera Guber, Alexandre Dubrac, Christian Beauséjour, Scott A. Armstrong, Frédérick A. Mallette, Christopher B. Yohn, Jean‐Sébastien Joyal, Dan Marquess, Pedro J. Beltran, Przemysław Sapieha

2021Cell Metabolism178 citationsDOIOpen Access PDF

Topics & Concepts

AngiogenesisNeovascularizationSenescenceDiabetic retinopathyPathologicalBiologyRetinalCancer researchRetinopathyChoroidal neovascularizationRetinaBlood vesselApoptosisCell biologyPathologyMedicineNeuroscienceDiabetes mellitusGeneticsEndocrinologyBiochemistryRetinal Diseases and TreatmentsRetinal Development and DisordersRetinal Imaging and Analysis
Pathological angiogenesis in retinopathy engages cellular senescence and is amenable to therapeutic elimination via BCL-xL inhibition | Litcius