Gravitational effects on intraocular pressure and ocular perfusion pressure
Lonnie G. Petersen, Richard S. Whittle, Justin H. Lee, Jeremy Sieker, Joseph J. Carlson, Colton Finke, Cody M. Shelton, Johan C. G. Petersen, Ana Diaz‐Artiles
Abstract
Maintaining appropriate ocular perfusion pressure (OPP) is critical for ocular health. We measured the relative changes in intraocular and mean arterial pressures during 360° tilt and calculated OPP, which was elevated during head-down tilt and decreased during head-up tilt. Experimental data are also explained by our computational model. We demonstrate that OPP is more gravitationally dependent than previously recognized and may be a factor in the overall patho-etiology behind the weightlessness-induced spaceflight-associated neuro-ocular syndrome.
Topics & Concepts
Intraocular pressurePerfusionOphthalmologyAnesthesiaIntracranial pressureMedicineCardiologySpaceflight effects on biologyOptical Imaging and Spectroscopy TechniquesGlaucoma and retinal disorders