Network pharmacology and experiments in vivo and in vitro reveal that the Jia-Wei-Bu-Shen-Yi-Qi formula (JWBSYQF) and its active ingredient baicalein ameliorate BLM-induced lung fibrosis in mice via PI3K/Akt signaling pathway
Hanlin Shi, Lingling Deng, Yaolong Zhou, Hang Yu, Xi Huang, Mengmeng Chen, Lei Yang, Jingcheng Dong
Topics & Concepts
MedicinePharmacologyActive ingredientPI3K/AKT/mTOR pathwayPulmonary fibrosisKEGGLungBleomycinBaicaleinIdiopathic pulmonary fibrosisSignal transductionCancer researchBiologyInternal medicineChemotherapyBiochemistryTranscriptomeGene expressionGeneInterstitial Lung Diseases and Idiopathic Pulmonary FibrosisFlavonoids in Medical ResearchChronic Obstructive Pulmonary Disease (COPD) Research