TFA/TBHP-promoted oxidative cyclisation for the construction of tetracyclic quinazolinones and rutaecarpine
Feng‐Cheng Jia, Tian-Zhi Chen, Xiao‐Qiang Hu
Abstract
An efficient TFA/TBHP-promoted oxidative cyclisation of readily available isatins with 1,2,3,4-tetrahydroisoquinolines has been firstly developed. The potential utility of this strategy was demonstrated by one-step synthesis of a natural alkaloid Rutaecarpin.
Topics & Concepts
RutaecarpineChemistryOxidative phosphorylationAlkaloidCombinatorial chemistryOrganic chemistryChromatographyBiochemistryQuinazolinone synthesis and applicationsSynthesis and Biological EvaluationMulticomponent Synthesis of Heterocycles