Clinically Relevant Influenza Virus Evolution Reconstituted in a Human Lung Airway-on-a-Chip
Longlong Si, Haiqing Bai, Crystal Yuri Oh, Lei Jin, Rachelle Prantil‐Baun, Donald E. Ingber
Abstract
The rapid evolution of viruses, such as influenza viruses and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is challenging the use and development of antivirals and vaccines. Studies of within-host viral evolution can contribute to our understanding of the evolutionary and epidemiological factors that shape viral global evolution as well as development of better antivirals and vaccines.
Topics & Concepts
VirologyVirusReassortmentBiologyInfluenza A virusViral evolutionOseltamivirGeneGeneticsMedicineGenomeCoronavirus disease 2019 (COVID-19)DiseasePathologyInfectious disease (medical specialty)Respiratory viral infections researchInfluenza Virus Research StudiesInnovative Microfluidic and Catalytic Techniques Innovation