Dansyl-triazole-based fluorescent macrocycle for selective detection of nitro-antibiotic drugs and protein interaction
Liya Thurakkal, Rakhi Mol K. M., Mintu Porel
Abstract
A novel dansyl-triazole-based fluorescent macrocycle with high Stokes shift and positive solvatochromism was developed. This is an excellent fluorescence sensor for selective detection of nitro-containing antibiotics and other nitro-heteroaromatics. Detection was possible in real samples/paper strips in submicromolar concentration. The interaction of the macrocycle with multiple proteins exhibited its bioactivity.
Topics & Concepts
NitroFluorescenceChemistryCombinatorial chemistryTriazoleFluorescent proteinAntibiotics1,2,4-TriazoleStereochemistryOrganic chemistryBiochemistryGreen fluorescent proteinGeneQuantum mechanicsAlkylPhysicsLuminescence and Fluorescent MaterialsAdvanced biosensing and bioanalysis techniquesMolecular Sensors and Ion Detection