Preconditioned extracellular vesicles from hypoxic microglia reduce poststroke AQP4 depolarization, disturbed cerebrospinal fluid flow, astrogliosis, and neuroinflammation
Wenqiang Xin, Yongli Pan, Wei Wei, Lars Tatenhorst, Irina Graf, Aurel Popa‐Wagner, Stefan T. Gerner, Sabine Huber, Ertuğrul Kılıç, Dirk M. Hermann, Mathias Bähr, Hagen B. Huttner, Thorsten R. Doeppner
Abstract
These findings show that hypoxic microglia may participate in protecting against stroke-induced brain damage by regulating poststroke inflammation, astrogliosis, AQP4 depolarization, and CSF flow due to EV release.
Topics & Concepts
AstrogliosisMicrogliaNeuroinflammationInflammationDepolarizationAstrocyteMedicineAquaporin 4PathologyNeuroscienceImmunologyBiologyEndocrinologyCentral nervous systemNeuroinflammation and Neurodegeneration MechanismsCerebrospinal fluid and hydrocephalusTraumatic Brain Injury and Neurovascular Disturbances