AKAP79/150 coordinates leptin-induced PKA signaling to regulate KATP channel trafficking in pancreatic β-cells
Veronica A. Cochrane, Zhongying Yang, Mark L. Dell’Acqua, Show‐Ling Shyng
Abstract
channel trafficking in β-cells, hence insulin secretion. The study further advances our knowledge of the downstream signaling events that may be targeted to restore insulin secretion regulation in β-cells defective in leptin signaling, such as those from obese individuals with type 2 diabetes.
Topics & Concepts
LeptinProtein kinase ACell biologyInternal medicineLeptin receptorEndocrinologyInsulinSignal transductionChemistryBiologyKinaseMedicineObesityPancreatic function and diabetesRegulation of Appetite and ObesityAdipose Tissue and Metabolism