Design of aggregation-induced emission-active fluorogen-based nanoparticles for imaging and scavenging Alzheimer's β-amyloid by photo-oxygenation
Luqi Liu, Wei Liu, Yan Sun, Xiaoyan Dong
Abstract
strain CL2006 and extended the lifespan by 4 days. Taken together, this multifunctional T-LD NP integrated Aβ-targeting, near-infrared fluorescence imaging, and photo-oxygenation, provides a new strategy for the development of multifunctional AIE photo-oxidants for the treatment of Alzheimer's disease.
Topics & Concepts
Reactive oxygen speciesChemistryBiophysicsOxygenationAmyloid (mycology)NanoparticleNeurotoxicityIn vivoCytotoxicityAmphiphileIn vitroNanotechnologyMaterials scienceBiochemistryPolymerToxicityBiologyOrganic chemistryCopolymerInorganic chemistryEcologyBiotechnologyAlzheimer's disease research and treatmentsCholinesterase and Neurodegenerative DiseasesTryptophan and brain disorders