RETRACTED: Design, Synthesis, and Biological Evaluation of Notopterol Derivatives as Triple Inhibitors of AChE/BACE1/GSK3β for the Treatment of Alzheimer’s Disease
Nan Wang, Wenjie Liu, Lijun Zhou, Wenwu Liu, Liang Xu, Xin Liu, Zihua Xu, Tianming Zhong, Qiong Wu, Xinming Jiao, Jiangxia Chen, Xinyue Ning, Xiaowen Jiang, Qingchun Zhao
Abstract
could ameliorate the impaired learning and memory in Aβ-induced AD mice. In conclusion, we reported the triple inhibitor of AChE/BACE1/GSK3β lead compounds based on a furocoumarin scaffold of notopterol for the first time, which provides a potential new strategy for the treatment of AD.
Topics & Concepts
AchéAcetylcholinesteraseTriple bondDiseaseNeuroscienceMedicinePharmacologyPsychologyChemistryBiochemistryEnzymeInternal medicineOrganic chemistryDouble bondCholinesterase and Neurodegenerative DiseasesAlzheimer's disease research and treatmentsComputational Drug Discovery Methods