Circulating Biomarkers in Hypertrophic Cardiomyopathy
Eldon Matthia, Michael L. Setteducato, Mohammed Elzeneini, Nicholas Vernace, Michael Salerno, Christopher M. Kramer, Ellen C. Keeley
Abstract
Hypertrophic cardiomyopathy is the most common genetic heart disease. Biomarkers, molecules measurable in the blood, could inform the clinician by aiding in diagnosis, directing treatment, and predicting outcomes. We present an updated review of circulating biomarkers in hypertrophic cardiomyopathy representing key pathologic processes including wall stretch, myocardial necrosis, fibrosis, inflammation, hypertrophy, and endothelial dysfunction, in addition to their clinical significance.
Topics & Concepts
MedicineHypertrophic cardiomyopathyCardiologyFibrosisCardiomyopathyMuscle hypertrophyInflammationMyocardial fibrosisMyocardial hypertrophyInternal medicineDiseaseBiomarkerPathologyHeart failureChemistryBiochemistryCardiomyopathy and Myosin StudiesGalectins and Cancer BiologyViral Infections and Immunology Research