Molecular Crystal Engineering of Organic Chromophores for NIR-II Fluorescence Quantification of Cerebrovascular Function
Yuanyuan Li, Xiaoxiao Fan, Yirun Li, Shunjie Liu, Clarence Chuah, Youhong Tang, Ryan T. K. Kwok, Jacky W. Y. Lam, Xuefeng Lu, Jun Qian, Ben Zhong Tang
Abstract
-DFA fluorophore displays an absolute QY of 0.4% with an emission extending to 1400 nm, which is favorable for NIR-II bioimaging. The cerebrovascular function, including cerebral blood flow and cerebrovascular reactivity of different conditions, is accurately quantified by a NIR-II fluorescence wide-field microscope. Our study provides a sight for designing NIR-II fluorophores, which is useful for studying cerebrovascular function.
Topics & Concepts
ChromophoreFluorophoreFluorescenceQuantum yieldMaterials scienceIntermolecular forceAcceptorCrystal (programming language)Single crystalNear-infrared spectroscopyChemistryPhotochemistryCrystallographyMoleculeOpticsOrganic chemistryPhysicsProgramming languageComputer scienceCondensed matter physicsNanoplatforms for cancer theranosticsLuminescence and Fluorescent MaterialsPerovskite Materials and Applications