Mitochondrial Glycerol-3-Phosphate Dehydrogenase Restricts HBV Replication via the TRIM28-Mediated Degradation of HBx
Canyu Liu, Kaitao Zhao, Yingshan Chen, Yongxuan Yao, Jielin Tang, Jingjing Wang, Chonghui Xu, Qi Yang, Yi Zheng, Yifei Yuan, Hao Sun, Yongli Zhang, Yuan Zhou, Jizheng Chen, Yun Wang, Chunchen Wu, Rongjuan Pei, Xinwen Chen
Abstract
The glycerol-3-phosphate (G3P) shuttle is important for the delivery of cytosolic reducing equivalents into mitochondria for oxidative phosphorylation. The study analyzed two key components of the G3P shuttle and identified GPD2 as a restriction factor in HBV replication. The findings revealed a novel mechanism of GPD2-mediated inhibition of HBV replication via the recruitment of TRIM28 for degrading HBx, and the HBx-GPD2 interaction could be another potential therapeutic target for anti-HBV drug development.
Topics & Concepts
BiologyOxidative phosphorylationMitochondrionPhosphorylationCytosolPhosphateCell biologyBiochemistryEnzymeHepatitis B Virus StudiesLiver Disease Diagnosis and TreatmentEndoplasmic Reticulum Stress and Disease