The continuous-flow electrosynthesis of 4-(sulfonylmethyl)isoquinoline-1,3(2<i>H</i>,4<i>H</i>)-diones from <i>N</i>-alkyl-<i>N</i>-methacryloyl benzamides under metal-free and oxidant-free conditions
Jia Xu, Zhao Yang, Jiawei Hua, Yang Lin, Mixue Bian, Yuguang Li, Chengkou Liu, Wei He, Zheng Fang, Kai Guo
Abstract
An efficient and green electrochemical continuous flow approach has been developed for the synthesis of 4-(sulfonylmethyl)isoquinoline-1,3(2<italic>H</italic>,4<italic>H</italic>)-diones through sulfonylation of alkenes under metal-free and oxidant-free conditions.
Topics & Concepts
IsoquinolineChemistryElectrosynthesisContinuous flowAlkylElectrochemistryMetalMedicinal chemistryStereochemistryOrganic chemistryElectrodePhysical chemistryMechanicsPhysicsSulfur-Based Synthesis TechniquesRadical Photochemical ReactionsCatalytic C–H Functionalization Methods