Organophotoredox-Catalyzed Decarboxylative C(sp<sup>3</sup>)–O Bond Formation
Shotaro Shibutani, Taiga Kodo, Mitsutaka Takeda, Kazunori Nagao, Norihito Tokunaga, Yusuke Sasaki, Hirohisa Ohmiya
Abstract
This manuscript reports a visible-light-mediated organosulfide catalysis that enables the decarboxylative coupling between simple aliphatic alcohol and tertiary or secondary alkyl carboxylic acid-derived redox active esters to produce a C(sp3)–O–C(sp3) fragment. Results of the coupling using other heteroatom nucleophiles such as water, amides, and thiols are also described.
Topics & Concepts
ChemistryNucleophileCatalysisHeteroatomDecarboxylationAlkylAlcoholCarboxylic acidMedicinal chemistryOrganic chemistryStereochemistrySulfur-Based Synthesis TechniquesRadical Photochemical ReactionsOxidative Organic Chemistry Reactions