Multimodal analysis for human ex vivo studies shows extensive molecular changes from delays in blood processing
Adam K. Savage, Miriam V. Gutschow, Tony Chiang, Kathy Henderson, Richard Green, Monica Chaudhari, Elliott Swanson, Alexander T. Heubeck, Nina Kondza, Kelli C. Burley, Palak C. Genge, Cara Lord, Tanja Smith, Zachary Thomson, Aldan Beaubien, Ed Johnson, Jeff Goldy, Hamid Bolouri, Jane H. Buckner, Paul Meijer, Ernest M. Coffey, Peter J. Skene, Troy R. Torgerson, Xiaojun Li, Thomas F. Bumol
Abstract
biology. Differences accumulating during an overnight rest (18 hours) could confound relevant biologic variance related to many underlying disease states.
Topics & Concepts
ProteomeTranscriptomePeripheral blood mononuclear cellEx vivoBiologyPhenotypeProteomicsGene expression profilingIn vivoImmunologyComputational biologyBlood cellBioinformaticsGene expressionIn vitroGeneGeneticsSingle-cell and spatial transcriptomicsAdvanced Proteomics Techniques and ApplicationsCancer Genomics and Diagnostics