Bypassing the bottlenecks in the shikimate and methylerythritol phosphate pathways for enhancing the production of natural products from methane in <i>Methylotuvimicrobium alcaliphilum</i> 20Z
Diep Ngoc Pham, Anh Duc Nguyen, So Hyeon Oh, Eun Yeol Lee
Abstract
A methanotroph-based production of natural compounds (indigo and α-farnesene) coupled with metabolic engineering strategies for unraveling bottlenecks in their biosynthesis pathways has been developed.
Topics & Concepts
Shikimate pathwayMethaneChemistryPhosphateProduction (economics)Natural (archaeology)Shikimic acidOrganic chemistryBiosynthesisBiologyEnzymeMacroeconomicsPaleontologyEconomicsMicrobial Metabolic Engineering and BioproductionMicrobial metabolism and enzyme functionBiochemical Acid Research Studies