[1,2,4]Triazolo[4,3-<i>a</i>]quinoxaline and [1,2,4]triazolo[4,3-<i>a</i>]quinoxaline-1-thiol-derived DNA intercalators: design, synthesis, molecular docking, <i>in silico</i> ADMET profiles and anti-proliferative evaluations
Khaled El‐Adl, Abdel‐Ghany A. El‐Helby, Helmy Sakr, Alaa Elwan
Abstract
In view of their DNA intercalation activities as anticancer agents, 17 novel [1,2,4]triazolo[4,3-<italic>a</italic>]quinoxaline derivatives have been designed, synthesized and evaluated against HepG2, HCT-116 and MCF-7 cells.
Topics & Concepts
QuinoxalineChemistryIntercalation (chemistry)Combinatorial chemistryDNAStereochemistryDocking (animal)Organic chemistryBiochemistryNursingMedicineSynthesis and Biological EvaluationSynthesis and biological activityCancer therapeutics and mechanisms