Bioimaging of glutathione variation for early diagnosis of hepatocellular carcinoma using a liver-targeting ratiometric near-infrared fluorescent probe
Xiaoyue Han, Yanlong Xing, Xinyu Song, Kun Dou, Fabiao Yu, Lingxin Chen
Abstract
, orthotopic HCC and pulmonary metastatic hepatoma mice models were employed for GSH imaging using two-dimensional and three-dimensional fluorescence molecular tomographic imaging systems. The bioimaging results offered direct evidence that GSH displayed varied concentrations during the progression of HCC. Therefore, the as-synthesized probe CyO-Disu could serve as a potential powerful tool for the early diagnosis and precise treatment of HCC using GSH as a reliable biomarker.
Topics & Concepts
Hepatocellular carcinomaFluorescenceGlutathioneLiver cancerInfraredCancer researchMaterials scienceChemistryBiologyBiochemistryOpticsEnzymePhysicsSulfur Compounds in BiologyRedox biology and oxidative stressMolecular Sensors and Ion Detection