Primary activation of<i>para</i>-quinone methides by chiral phosphoric acid for enantioselective construction of tetraarylmethanes
Zhengyu Han, Biao Zhu, Yu Zang, Chaoshen Zhang, Xiu‐Qin Dong, Hai Huang, Jianwei Sun
Abstract
Demonstrated here is an asymmetric nucleophilic addition via primary activation of para -quinone methides ( p -QMs) based on a chiral phosphoric acid catalytic system.
Topics & Concepts
Enantioselective synthesisPhosphoric acidPrimary (astronomy)QuinoneChemistryOrganic chemistryCombinatorial chemistryCatalysisPhysicsAstronomySynthesis of Indole DerivativesAxial and Atropisomeric Chirality SynthesisMulticomponent Synthesis of Heterocycles