Protective role of Siberian onions against toxin-induced liver dysfunction: an insight into health-promoting effects
Yuchen Jiang, Xin Han, Jia-Yi Dou, Ming-Hui Yuan, Mei-Jie Zhou, Zhenyu Cui, Li‐Hua Lian, Ji‐Xing Nan, Xian Zhang, Yan‐Ling Wu
Abstract
-induced mice, including α-SMA, collagen-I and TIMP-1. SO reduced the release of inflammatory factors and regulated apoptosis-associated proteins, which is related to the inhibition of STAT3 phosphorylation. Moreover, SO reduced the positive expressions of α-SMA and NLRP3 by inhibiting STAT3 phosphorylation in activated HSCs. SO could show health-promoting effects for liver dysfunction by alleviating hepatic fibrogenesis, apoptosis and inflammation in the development of hepatic fibrosis potential depending on the STAT3 signaling pathway.
Topics & Concepts
Oxidative stressSTAT proteinSTAT3PharmacologyApoptosisInflammationChemistryHepatic stellate cellFibrosisCYP2E1CCL4MedicineBiochemistryImmunologyInternal medicineCarbon tetrachlorideIn vitroOrganic chemistryMicrosomeLiver physiology and pathologyDrug-Induced Hepatotoxicity and ProtectionLiver Disease Diagnosis and Treatment