Azulene-based fluorescent chemosensor for adenosine diphosphate
Carlos M. López-Alled, Sang Jun Park, Dong Joon Lee, Lloyd C. Murfin, Gabriele Kociok‐Köhn, Jodie L. Hann, Jannis Wenk, Tony D. James, Hwan Myung Kim, Simon E. Lewis
Abstract
AzuFluor® 435-DPA-Zn, an azulene fluorophore bearing two zinc(II)-dipicolylamine receptor motifs, exhibits fluorescence enhancement in the presence of adenosine diphosphate. Selectivity for ADP over ATP, AMP and PPi results from appropriate positioning of the receptor motifs, since an isomeric sensor cannot discriminate between ADP and ATP.
Topics & Concepts
AzuleneFluorescenceFluorophoreChemistryAdenosine diphosphatePhotochemistryAdenosineBiochemistryPlatelet aggregationPlateletQuantum mechanicsPhysicsImmunologyBiologyMolecular Sensors and Ion DetectionLuminescence and Fluorescent MaterialsSupramolecular Chemistry and Complexes