Recent trends in catalytic sp<sup>3</sup> C–H functionalization of heterocycles
Milanpreet Kaur, Jeffrey F. Van Humbeck
Abstract
C-H functionalization on alkyl side-chain substituents-especially at the heterobenzylic position-with more than two hundred manuscripts published just within the last ten years. Rather than describing in detail each of these reports, in this mini-review we attempt to highlight gaps in existing techniques. A semi-quantitative overview of ongoing work strongly suggests that several specific heterocycle types and bond formations outside of C-C, C-N, and C-O have been almost completely overlooked.
Topics & Concepts
Surface modificationCatalysisChemistryCombinatorial chemistryOrganic chemistryPhysical chemistryCatalytic C–H Functionalization MethodsSynthesis and Catalytic ReactionsCyclopropane Reaction Mechanisms