The Effects of a High-Fat Diet on Inflammatory Bowel Disease
Yuan Dang, Chunxiang Ma, Kexin Chen, Yiding Chen, Mingshan Jiang, Kehan Hu, Lili Li, Zhen Zeng, Hu Zhang
Abstract
The interactions among diet, intestinal immunity, and microbiota are complex and play contradictory roles in inflammatory bowel disease (IBD). An increasing number of studies has shed light on this field. The intestinal immune balance is disrupted by a high-fat diet (HFD) in several ways, such as impairing the intestinal barrier, influencing immune cells, and altering the gut microbiota. In contrast, a rational diet is thought to maintain intestinal immunity by regulating gut microbiota. In this review, we emphasize the crucial contributions made by an HFD to the gut immune system and microbiota.
Topics & Concepts
Immune systemGut floraImmunityInflammatory bowel diseaseBiologyImmunologyDiseaseMedicineInternal medicineGut microbiota and healthInflammatory Bowel DiseaseIL-33, ST2, and ILC Pathways