Identification and validation of hypoxia-derived gene signatures to predict clinical outcomes and therapeutic responses in stage I lung adenocarcinoma patients
Run Shi, Xuanwen Bao, Kristian Unger, Jing Sun, Shun Lu, Farkhad Manapov, Xuanbin Wang, Claus Belka, Minglun Li
Abstract
In summary, the proposed hypoxia-derived signatures are promising biomarkers to predict clinical outcomes and therapeutic responses in stage I LUAD patients.
Topics & Concepts
NomogramOncologyMedicineAdenocarcinomaInternal medicineStage (stratigraphy)Proportional hazards modelLung cancerSurvival analysisHypoxia (environmental)BioinformaticsCancerBiologyOxygenChemistryOrganic chemistryPaleontologyCancer-related molecular mechanisms researchRNA modifications and cancerFerroptosis and cancer prognosis