Genetically and environmentally predicted obesity in relation to cardiovascular disease: a nationwide cohort study
Elsa Ojalehto, Yiqiang Zhan, Juulia Jylhävä, Chandra A. Reynolds, Anna K. Dahl Aslan, Ida Karlsson
Abstract
Background: Evidence indicates that the adverse health effects of obesity differ between genetically and environmentally influenced obesity. We examined differences in the association between obesity and cardiovascular disease (CVD) between individuals with a genetically predicted low, medium, or high body mass index (BMI). Methods: . Findings: . Results were similar when obesity was measured in late-life, but suffered from low power. Interpretation: , still influence the associations. Funding: The Strategic Research Program in Epidemiology at Karolinska Institutet; Loo and Hans Osterman's Foundation; Foundation for Geriatric Diseases at Karolinska Institutet; the Swedish Research Council for Health, Working Life and Welfare; the Swedish Research Council; and the National Institutes of Health.