Clinical efficacy of PARP inhibitors in breast cancer
Karan Pandya, Alyssa Scher, Coral Omene, Shridar Ganesan, Shicha Kumar, Nisha Ohri, Lindsay Potdevin, Bruce G. Haffty, Deborah Toppmeyer, Mridula George
Topics & Concepts
OlaparibSynthetic lethalityPARP1Breast cancerDNA repairPARP inhibitorCancer researchHomologous recombinationBRCA2 ProteinGermline mutationOvarian cancerGermlineBiologyPoly ADP ribose polymeraseCancerMedicineMutationGeneticsGenePolymerasePARP inhibition in cancer therapyDNA Repair MechanismsBRCA gene mutations in cancer