Metal–Organic Frameworks-Based Nanoplatform for Treatment of Breast Cancer
Yi Li, Huilin Sun, Chenxue Yang, Zihui Yan, Jing‐Yuan Ge, Jianhao Wang, Zhongyan Chen, Lin Qiu, Yang Bai
Abstract
Nanoscaled metal–organic frameworks (MOFs) have great prospects in drug delivery. As a unique architecture, MOF-on-MOF has emerged as a promising strategy to enhance drug loading and release efficacy. Herein, a ZIF-8-on-ZIF-8 nanoplatform has been fabricated via the MOF-on-MOF strategy for doxorubicin (DOX) loading, resulting in a core–shell hierarchical nanostructure (DOX@ZIF-8-on-ZIF-8, DZZ). This unique nanoplatform exhibited pH and GSH dual-responsive DOX-releasing behavior, which are features of the tumor microenvironment (TME). Compared to monolayer DOX-encapsulated monolayer ZIF-8 (DOX@ZIF-8, DZ), DZZ can significantly increase the drug loading efficiency (DLE) by 56-fold, increase drug encapsulation efficiency (DEE) by 25-fold, enhance the penetration depth of DOX, and improve the selective inhibition on breast cancer 4T1 cells both in vitro and in vivo. Such a ZIF-on-ZIF nanoplatform provides an efficient strategy for tumor-targeted drug delivery and breast cancer treatments.