Inhibition of Smad3 in macrophages promotes Aβ efflux from the brain and thereby ameliorates Alzheimer's pathology
Lu Xu, Cailong Pan, Xiang‐Hui Wu, Jingjing Song, Ping Meng, Lei Li, Li Wang, Zhiren Zhang, Zhiren Zhang, Zhi-Yuan Zhang, Zhi-Yuan Zhang
Topics & Concepts
NeuroinflammationGenetically modified mouseMacrophageMicrogliaPathogenesisPhagocytosisImmune systemNeuroscienceTransgeneCell biologyPhenotypeIntracellularBiologyImmunologyPathologyMedicineInflammationIn vitroGeneBiochemistryAlzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration MechanismsNuclear Receptors and Signaling