Evaluation of novel pyrazol-4-yl pyridine derivatives possessing arylsulfonamide tethers as c-Jun N-terminal kinase (JNK) inhibitors in leukemia cells
Karim I. Mersal, Mohammed S. Abdel‐Maksoud, Eslam M.H. Ali, Usama M. Ammar, Seyed–Omar Zaraei, Md. Mamunul Haque, Tanuza Das, Noha F. Hassan, Eunice EunKyeong Kim, Jun‐Seok Lee, HaJeung Park, Kwan H. Lee, Mohammed I. El–Gamal, Hee-Kwon Kim, Tamer M. Ibrahim, Chang‐Hyun Oh, Chang‐Hyun Oh
Topics & Concepts
ChemistryKinaseIC50PotencyCytotoxicityCell cultureK562 cellsApoptosisStereochemistryMolecular biologyBiochemistryIn vitroBiologyGeneticsMelanoma and MAPK PathwaysQuinazolinone synthesis and applicationsCancer therapeutics and mechanisms