Bim- and Bax-mediated mitochondrial pathway dominates abivertinib-induced apoptosis and ferroptosis
Qiling Tang, Hongce Chen, Zihao Mai, Han Sun, Lingjun Xu, Guihao Wu, Zhuang Tu, Xuecheng Cheng, Xiaoping Wang, Tongsheng Chen
Topics & Concepts
ApoptosisReactive oxygen speciesGPX4Cell biologyChemistryMitochondrial ROSProgrammed cell deathMitochondrionMolecular biologyBiologyOxidative stressBiochemistryGlutathione peroxidaseSuperoxide dismutaseFerroptosis and cancer prognosisDrug Transport and Resistance MechanismsPhagocytosis and Immune Regulation